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Contraindicated (one)pentobarbital will reduce the level or outcome of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Girls mustn't opt for estradiol valerate/dienogest as their contraceptive although working with sturdy CYP3A4 inducers because of prospective lessen in contraceptive efficacy.

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